Genomic Spotlight using Opus23 identifies how the function of one gene or SNP impacts the expression and function of a separately related gene or SNP, and ultimately a subject’s physiology. Using this platform, clinicians can customize reports with an interactive dashboard that curates a subject’s genomic data in “real-time” by using the latest literature databases and meta-data sets providing relevant information on nutritional supplements, diet, and lifestyle changes that can proactively influence a subject’s gene expression and function, and ultimately their health and well-being.